SP-0221: EGFR-inhibitors, radiotherapy and normal tissue toxicity
نویسندگان
چکیده
منابع مشابه
Radiotherapy plus EGFR inhibitors: synergistic modalities
Locally advanced (stage III or IV) squamous cell carcinoma of the head and neck (SCCHN) often requires multimodal treatment, consisting of a combination of surgery, radiation, and/or systemic therapy, namely chemotherapy or targeted agents. The expression of the epidermal growth factor receptor (EGFR) has been detected in more than 90% of all cases of SCCHN and has been correlated with decrease...
متن کاملInfluence of daily imaging on plan quality and normal tissue toxicity for prostate cancer radiotherapy
BACKGROUND Modern radiotherapy offers various possibilities for image guided verification of patient positioning. Different clinically relevant IGRT (image guided radiotherapy) scenarios were considered with regard to their influence on dosimetric plan quality and normal tissue complication probability (NTCP). METHODS This study is based on treatment plans of 50 prostate patients. We evaluate...
متن کاملPredicting Normal Tissue Complications In Radiotherapy
.> Introduction Patient-to-patient variations in the radiosensitivity of normal and neoplastic tissues are well known and recognized both in vivo(1.2) and in vitro studies. (3.6) The typical example is the autosomal recessive disease ataxia-telangiectasia (AT). ATM patients are extremely sensitive to ionizing radiation. The patients develop severe to fatal radiation reactions when treated by st...
متن کاملReduced Normal Tissue Toxicity with Proton Therapy
Proton beams offer highly significant advantages over X-rays in the sparing of normal tissues. This is due to the physical characteristics of the proton beam compared to X-rays. X-rays are electromagnetic waves and are highly penetrating, and will deliver dose throughout any volume of tissue irradiated, regardless of thickness. Thus x-rays always deliver substantial doses of irradiation both an...
متن کاملLocal Tumor Control and Normal Tissue Toxicity of Pulsed Low-Dose Rate Radiotherapy for Recurrent Lung Cancer
OBJECTIVES This study investigates (1) local tumor control and (2) normal tissue toxicity of pulsed low-dose rate radiotherapy (PLDR) for recurrent lung cancer. METHODS For study 1, nude mice were implanted with A549 tumors and divided into the following 3 groups: (1) control (n = 10), (2) conventional radiotherapy (RT; n = 10), and (3) PLDR (n = 10). Tumor-bearing mice received 2 Gy daily do...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2015
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)40219-1